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Abstract #26111 Published in IGR 12-2
Influence of height, weight, and body mass index on optic disc parameters
Zheng Y; Cheung CY; Wong TY; Mitchell P; Aung TInvestigative Ophthalmology and Visual Science 2010; 51: 2998-3002
PURPOSE: To examine the influence of body height, body weight, and body mass index (BMI) on optic disc parameters in a population-based study. METHODS: The Singapore Malay Eye Study examined 3280 persons of Malay ethnicity, aged 40 to 80 years, of whom 2329 (71.0%) had reliable retinal scanning confocal laser tomography images for analyses. Intraocular pressure (IOP) was ascertained by Goldmann applanation tonometry. Body height and weight were measured with standardized protocols; BMI was calculated as weight (kilograms)/height squared (meters). Sociodemographic information was collected in an interviewer-administered questionnaire. RESULTS: In univariate analyses, body height, weight, and BMI were significantly associated with optic cup area, rim area, and cup-to-disc area ratio (all with P < 0.05) but none of the anthropometric parameters was significantly associated with optic disc area (all with P > 0.05). In multiple regression analyses after adjustment for age, sex, optic disc size, axial length, education, family income, and IOP, each SD increase in body height was associated with a 0.042-mm(2) decrease in optic rim area and a 0.020 increase in optic cup-to-disc area ratio; each SD decrease in body weight was associated with a 0.013-mm(2) decrease in optic rim area and a 0.010 increase in optic cup-to-disc ratio; and each SD decrease in BMI was associated with a 0.021-mm(2) decrease in optic rim area and a 0.010 increase in optic cup-to-disc ratio. CONCLUSIONS: Persons who are taller or have lower BMI have a smaller neuroretinal rim area and a larger optic cup-to-disc area ratio.
Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
Classification:
15 Miscellaneous
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
