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Abstract #26659 Published in IGR 12-3
A correlation between latanoprost-induced conjunctival hyperemia and intraocular pressure-lowering effect
Kobayashi H; Kobayashi KJournal of Glaucoma 2010;
PURPOSE: To study any correlation between a short-term change in conjunctival hyperemia severity and the intraocular pressure-lowering effect induced by latanoprost. PATIENTS AND METHODS: A 114 patients (56 females and 58 males) with open-angle glaucoma or ocular hypertension were studied. Their mean age was 60.9(plus or minus)15.0 years (range, 25 to 87 y). The primary outcome measure was the change in conjunctival hyperemia grade at 2 days and the change in intraocular pressure at 6 months after the start of latanoprost administration. RESULTS: Mean intraocular pressure before and 6 months after latanoprost administration was 22.5(plus or minus)3.8 mm Hg and 16.5(plus or minus)2.9 mm Hg, respectively (P<0.0001). Mean conjunctival hyperemia grade before and 2 days after the administration of latanoprost was 0.32(plus or minus)0.58 and 1.74(plus or minus)1.11, respectively (P<0.0001). Mean change in intraocular pressure was -1.7(plus or minus)1.2 mm Hg (-6.6(plus or minus)5.1%) in eyes with no hyperemia grade change, -5.2(plus or minus)2.2 mm Hg (-21.5(plus or minus)7.6%) in eyes with a hyperemia grade change of 1, -7.3(plus or minus)2.8 mm Hg (-32.0(plus or minus)8.9%) in eyes with a change of 2, and -10.8(plus or minus)2.7 mm Hg (-46.1(plus or minus)8.6%) in eyes with a change of 3 or 4 (P<0.0001). There was a significant correlation between intraocular pressure change and hyperemia grade change (intraocular pressure: r=0.535, P=0.0001; percent of intraocular pressure: r=0.755, P=0.0001). CONCLUSION: A statistically significant correlation was found between a change in intraocular pressure and conjunctival hyperemia severity induced by latanoprost.
H. Kobayashi.
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)