advertisement
Abstract #27149 Published in IGR 12-4
Glaucoma: Genes, phenotypes, and new directions for therapy
Fan BJ; Wiggs JLJournal of Clinical Investigation 2010; 120: 3064-3072
Glaucoma, a leading cause of blindness worldwide, is characterized by progressive optic nerve damage, usually associated with intraocular pressure. Although the clinical progression of the disease is well defined, the molecular events responsible for glaucoma are currently poorly understood and current therapeutic strategies are not curative. This review summarizes the human genetics and genomic approaches that have shed light on the complex inheritance of glaucoma genes and the potential for gene-based and cellular therapies that this research makes possible.
J. L. Wiggs. Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St., Boston, MA, United States. janey_wiggs@meei.harvard.edu
Classification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
