advertisement
Abstract #27330 Published in IGR 12-4
24-h Intraocular pressure control with evening-dosed travoprost/timolol, compared with latanoprost/timolol, fixed combinations in exfoliative glaucoma
Konstas AGP; Mikropoulos DG; Embeslidis TA; Dimopoulos AT; Papanastasiou A; Haidich A-B; Stewart WCEye 2010; 24: 1606-1613
PurposeTo evaluate 24-h efficacy of travoprost/timolol fixed combination (TTFC) vslatanoprost/timolol fixed combination (LTFC) in exfoliative glaucoma (XFG).DesignA prospective, single-masked, crossover, active-controlled, randomized 24-h comparison.MethodsAfter up to a 6-week medicine-free period, XFG patients were randomized to either TTFC or LTFC for 3 months, dosed each evening, and then changed to the opposite treatment for another 3 months. At the end of the washout, and both treatment periods, a 24-h intraocular pressure (IOP) curve was measured.ResultsIn total, 40 patients completed the study. The TTFC group showed a lower mean absolute 24-h IOP (18.7(plus or minus)2.6 vs19.6(plus or minus)2.6 mm Hg, P<0.001), maximum IOP (20.5(plus or minus)2.6 vs21.5(plus or minus)2.6 mm Hg, P<0.001) and 24-h IOP range (3.4(plus or minus)1.3 vs4.1(plus or minus)1.6 mm Hg, P=0.01). At individual time points, TTFC showed reduced IOPs compared with LTFC, after a Bonferroni correction, at 1000, 1800, and 2200 hours (P(less-than or equal to)0.04). No statistical differences existed at hours: 0600, 1400, and 0200 (P(greater-than or equal to)0.05) and for the minimum IOP (P=0.09).ConclusionsThis study suggests that evening-dosed TTFC may provide greater 24-h IOP reduction, primarily at the 1800 hours time point, compared with LTFC in XFG. (copyright) 2010 Macmillan Publishers Limited All rights reserved.
W. C. Stewart. Department of Ophthalmology, PRN Pharmaceutical Research Network, LLC, 6296 Rivers Avenue, Charleston, SC 29406, United States. info@prnorb.com
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
