advertisement
Abstract #27348 Published in IGR 12-4
Prevalence of ocular disorders in patients affected with sleep apnoea syndrome
Chambe J; Laib S; Erhardt C; Schroder C; Ruppert E; Bourcier T; Bourgin PJournal of Sleep Research 2010; 19: 305
Objectives: Recent studies suggest an association between obstructive sleep apnea/hypopnea syndrome (OSAS) and ocular pathologies such as floppy eyelid syndrome (FES), chronic glaucoma, anterior ischemic optic neuropathy (NOIAA), papillar oedema and keratoconus. However, because of the low sample size and contradictory results, additional data are needed in order to determine if there is an association between eye disease and OSAS. Methods: We performed a monocentric prospective study which included 160 patients referred to the sleep clinic for symptoms of respiratory sleep disorders. All patients completed sleep questionnaires, underwent a clinical exam, an ambulatory respiratory polygraphy and a comprehensive ophthalmological examination (visual acuity, intraocular pressure, corneal thickness, OCT fiber analysis, corneal topography, visual field Hymphrey 30-2 and an eyelid examination). The patients were distributed into different groups according to the severity of the sleep respiratory disorder (control, light, moderate and severe). The polygraphic recordings were analysed by two independent scorers and the ophthalmologist was not aware of the polygraphic results. Results: Preliminary analysis consisted of 82 patients (29 control, 30 light, 13 moderate, and 10 severe OSAS). 52% of moderate and severe OSAS subjects displayed FES, as compared with 34% of control patients. Spearman rank correlation showed a significant (P = 0.019) relation between FES and time spent with an oxygen desaturation under 90%, and between FES and snoring (P = 0.0056). Chronic glaucoma was present in 7.3% of the total number of subjects, which is higher than the prevalence usually observed in a comparable population. In addition, it was evenly distributed between controls and patients suffering from OSAS. No significant association was found between glaucoma and OSAS. Furthermore, we did not observe any cases of NOIAA or keratoconus, though these pathologies have a very low prevalence. Conclusion: Continuing analysis of 160 patients is currently under way. Our preliminary results suggest an association between snoring and FES as well as between oxygen desaturation and FES which raises the question as to whether a complete ophthalmological evaluation should be systematically given to all OSAS patients.
J. Chambe. University of Strasbourg, StrasbourgFrance.
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
