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Abstract #27361 Published in IGR 12-4
Ultrastructure of trabecular tissue in primary angle-close glaucoma of Mongolia
Cui W; Sun X-L; Li H-XChinese Ophthalmic Research 2010; 28: 650-653
Background: Research showed that the incidence of primary angle close glaucoma (PACG) is higher in Mongolia population than the Han nationality, but the mechanism is still under investigation. Objective: This study tried to investigate the ultrastructure of anterior chamber angle tissue in primary angle-close glaucoma (PACG) in Mongolia and explore the relationship between the anatomic factor and incidence of PACG in Mongolia nationality. Methods: The trabcular meshwork tissue was obtained from 30 Mongolia patients and Han nationality patients with PACG during the filtering surgery. The PACG was diagnosed upon the criteria of Glaucoma Group of Chinese Ophthalmology Association. The ultrastructure of trabcular meshwork, including collagen fibers, endothelial cells, cortical area, trabecular meshwork hole were examined under the transmission electron microscope. Twenty samples of trabecular meshwork were from Mongolias and 20 Han nationality donors respectively. Results: The characters of trabecular tissue of normal Mongolia was as follows: the collagen fibers of trabecular meager plate was intact but arranged disorderly. No well-defined boundary was displayed between collagen fibers axis and basal membrane. In Mongolia PACG patients, the disorder of trabecular meager fiber plate, rupture of collagen fibers, karyolysis of endothelial cell of trabecular meager plate, lessen of cellular organs were seen. The cortex bank of trabecular meager plate showed a definite lines with broken collagen fibers and hyaline degeneration. The narrow of trabecular meshwork also was found. The numbers of samples of ultrastructure abnormality in normal population of Mongolia nationality were increased in compared with those of Han nationality, including the significant differences in collagen fibers abnormality ((chi)(2) = 4.360, P = 0.025), endothelial cells abnormality ((chi)(2) = 6.570, P = 0.013), cortical areas abnormality ((chi)(2) = 7.140, P = 0.035) and trabecular meshwork hole ((chi)(2) = 5.430, P = 0.020). The numbers of samples of ultrastructure abnormality in Mongolia PACG patients were increased in compared with those of Han nationality, showing a statistically significant differences in collagen fibers abnormality ((chi)(2) = 4.250, P = 0.026), endothelial cells abnormality ((chi)(2) = 7.180, P = 0.037), cortical areas abnormality ((chi)(2) = 6.540, P = 0.013) and trabecular meshwork hole ((chi)(2) = 5.270, P = 0.019). Conclusion: The structure of trabecular tissue exists difference in both normal population and PACG patients in Mongolia in comparison with Han nationality. The sallow anterior chamber, narrow angle and abnormality of ultrastructure of trabecular tissue are relevant high risk factors to the high incidence of glaucoma in Mongolia. LA: Chinese
W. Cui. Department of Ophthalmology, Hospital of Inner Mongolia Autonomous Region, Huhhot 010017, China. CuiWei1957yanke@163.com
Classification:
9.3.2 Chronic primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
2.5.1 Trabecular meshwork (Part of: 2 Anatomical structures in glaucoma > 2.5 Meshwork)