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Abstract #27836 Published in IGR 13-1
Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging
Choi SS; Zawadzki RJ; Lim MC; Brandt JD; Keltner JL; Doble N; Werner JSBritish Journal of Ophthalmology 2011; 95: 131-141
See also comment(s) by Michael Nork •
Aims: It is well established that glaucoma results in a thinning of the inner retina. To investigate whether the outer retina is also involved, ultrahigh-resolution retinal imaging techniques were utilised. Methods: Eyes from 10 glaucoma patients (25-78 years old), were imaged using three research-grade instruments: (1) ultrahigh-resolution Fourier-domain optical coherence tomography (UHR-FD-OCT), (2) adaptive optics (AO) UHR-FD-OCT and (3) AO-flood illuminated fundus camera (AO-FC). UHR-FD-OCT and AO-UHR-FD-OCT B-scans were examined for any abnormalities in the retinal layers. On some patients, cone density measurements were made from the AO-FC en face images. Correlations between retinal structure and visual sensitivity were measured by Humphrey visual-field (VF) testing made at the corresponding retinal locations. Results: All three in vivo imaging modalities revealed evidence of outer retinal changes along with the expected thinning of the inner retina in glaucomatous eyes with VF loss. AO-UHR-FD-OCT images identified the exact location of structural changes within the cone photoreceptor layer with the AO-FC en face images showing dark areas in the cone mosaic at the same retinal locations with reduced visual sensitivity. Conclusion: Losses in cone density along with expected inner retinal changes were demonstrated in well-characterised glaucoma patients with VF loss.
S. S. Choi. New England College of Optometry, 424 Beacon Street, Boston, MA 02115, United States. chois@neco.edu
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.9.5 Other (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
6.8.2 Posterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)