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Abstract #27985 Published in IGR 13-1
Neurodegeneration in glaucoma: Progression and calcium-dependent intracellular mechanisms
Crish SD; Calkins DJNeuroscience 2011; 176: 1-11
Glaucoma is an age-related optic neuropathy involving sensitivity to ocular pressure. The disease is now seen increasingly as one of the central nervous system, as powerful new approaches highlight an increasing number of similarities with other age-related neurodegenerations such as Alzheimer's and Parkinson's. While the etiologies of these diseases are diverse, they involve many important common elements including compartmentalized programs of degeneration targeting axons, dendrites and finally cell bodies. Most age-related degenerations display early functional deficits that precede actual loss of neuronal substrate. These are linked to several specific neurochemical cascades that can be linked back to dysregulation of Ca(2+)-dependent processes. We are now in the midst of identifying similar cascades in glaucoma. Here we review recent evidence on the pathological progression of neurodegeneration in glaucoma and some of the Ca(2+)-dependent mechanisms that could underlie these changes. These mechanisms present clear implications for efforts to develop interventions targeting neuronal loss directly and make glaucoma an attractive model for both interrogating and informing other neurodegenerative diseases. (copyright) 2011 IBRO.
D.J. Calkins. Vanderbilt Eye Institute and Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232, United States. david.j.calkins@vanderbilt.edu
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
3.9 Pathophysiology (Part of: 3 Laboratory methods)
3.8 Pharmacology (Part of: 3 Laboratory methods)