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Abstract #28000 Published in IGR 13-1
The parameters of the porcine eyeball
Sanchez I; Martin R; Ussa F; Fernandez-Bueno IGraefe's Archive for Clinical and Experimental Ophthalmology 2011; 1-8
Background: The eye of the domestic pig (Sus scrofa domestica) is an ex vivo animal model often used in vision sciences research (retina studies, glaucoma, cataracts, etc.). However, only a few papers have compiled pig eye anatomical descriptions. The purpose of this paper is to describe pig and human eye anatomical parameters to help investigators in their choice of animal model depending on their study objective. Methods: A wide search of current medical literature was performed (English language) using PubMed. Anteroposterior axial length and corneal radius, astigmatism, vertical and horizontal diameter, and pachymetry (slit-scan and ultrasound) were measured in five enucleated pig eyes of animals 6 to 8 months old. Results: Horizontal corneal diameter was 14.31 (plus or minus) 0.25 mm (CI 95% 14.03 mm-14.59 mm), vertical diameter was 12.00 (plus or minus) 0 mm, anteroposterior length was 23.9 (plus or minus) 0.08 mm (CI 95% 23.01 mm-29.99 mm), central corneal ultrasound pachymetry was 877.6 (plus or minus) 13.58 (mu)m (CI 95% 865.70 (mu)m-889.50 (mu)m) and slit-scan pachymetry was 906.2 (plus or minus) 15.30 (mu)m (CI 95% 892.78 (mu)m-919.61 (mu)m). Automatic keratometry (main meridians) was 41.19 (plus or minus) 1.76D and 38.83 (plus or minus) 2.89D (CI 95% 40.53D-41.81D and 37.76D-39.89D respectively) with an astigmatism of 2.36 (plus or minus) 1.70D (CI 95% 1.72D-3.00D), and manual keratometry was 41.05 (plus or minus) 0.54D and 39.30 (plus or minus) 1.15D (CI 95% 40.57D-41.52D and 38.29D-40.31D respectively) with an astigmatism of 1.75 (plus or minus) 1.31D (CI 95% 0.60D-2.90D). Conclusion: This paper describes the anatomy of the pig eyeball for easy use and interpretation by researchers who are considering their choice of animal model in vision sciences research. (copyright) 2011 Springer-Verlag.
I. Sanchez. IOBA-Eye Institute and CIBER-BBN, University of Valladolid, Valladolid, Spain. isanchezp@ioba.med.uva.es
Classification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)