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Abstract #28024 Published in IGR 13-1
Pattern electroretinogram association with spectral domain-OCT structural measurements in glaucoma
Bowd C; Tafreshi A; Zangwill LM; Medeiros FA; Sample PA; Weinreb RNEye 2011; 25: 224-232
PurposeTo describe the association between pattern electroretinogram (PERG) amplitude and spectral domain-optical coherence tomography (SD-OCT) macular thickness, retinal nerve fibre layer (RNFL) thickness and optic disc topography measurements.Subjects and methodsBoth eyes (n=132) of 66 glaucoma patients (mean age=67.9 years) enroled in the University of California, San Diego, CA, USA, Diagnostic Innovations in Glaucoma Study (DIGS) were included. Eyes were tested with PERG (Glaid PERGLA, Lace Elettronica, Pisa, Italy), RTVue SD-OCT (Optovue Inc., Fremont, CA, USA) GCC, and NHM4 protocols on the same day. Of the 66 enroled patients, 43 had glaucoma defined by repeated abnormal standard automated perimetry (SAP) results in at least one eye and 23 were glaucoma suspects defined by a glaucomatous-appearing optic disc by physicians examination in at least one eye and normal SAP results in both eyes. Associations (R (2)) were determined between PERG amplitude ((mu)V) and SD-OCT macular ganglion cell complex (GCC) thickness ((mu)m), macular thickness ((mu)m), macular outer retinal thickness (macular thickness minus GCC thickness) (m), RNFL thickness (m), neuroretinal rim area (mm(2)), and rim volume (mm(3)).Results PERG amplitude was significantly associated with GCC thickness (R(2) 0.179, P<0.001), RNFL thickness (R (2) 0.174, P<0.001), and macular thickness (R 2 0.095, P<0.001). R(2) associations with other parameters were not significant (all P>0.624). Significant associations remained for GCC and average RNFL thickness when age and intraocular pressure at the time of testing were included in multivariate models (both P(less-than or equal to)0.030).ConclusionsPERG amplitude is significantly (but weakly) associated with macular GCC thickness, RNFL thickness, and macular thickness. The lack of association between PERG amplitude and macular outer retinal thickness supports previous results, possibly suggesting that that the PERG is driven primarily by retinal ganglion cell (inner retinal) responses.
C. Bowd. Hamilton Glaucoma Center-178, Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 9203-0946, United States. cbowd@glaucoma.ucsd.edu
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)