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Abstract #28046 Published in IGR 13-1
Research progress of prostaglandin receptors and related drugs
Xu H; Sun H-BJournal of China Pharmaceutical University 2010; 41: 385-394
Prostaglandins is a kind of endogenous compounds with extensive physiological activities, and more than twenty kinds of natural prostaglandins have been found, while about two thousand prostanoid have been synthetized. These compounds have been developed as therapie agents, which are used in alimentary system, cardiovascular system, genital system and anti-glaucoma. Numerous types of prostaglandin receptors exist in organism, belonging to G-protein-coupled receptor superfamily, mediate multiple physiological and pathological processes, such as asthma, pain and inflammation. This review summarizes the properties of each type of prostaglandin receptor, and the clinical applications and research progress of drugs targeting their corresponding prostaglandin receptors. LA: Chinese
H. Xu. Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China.
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
