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Abstract #28048 Published in IGR 13-1
Neuro-protective effects of yiyanming solution on visual function of glaucoma patient
Wang Y; Qiu B; Zhang C-X; Ou Y; Pang L; Li Z-PChinese Ophthalmic Research 2010; 28: 1087-1090
Background: Loss of retinal ganglion cells (RGCs) is a dominant feature of optic nerve in glaucoma. Our previous study showed that traditional Chinese herbs have a neuoprotective effect on RGCs. Objective: This study was to evaluate the protective effect of yiyanming on optic nerve in glaucoma patient after controlled intraocular pressure (IOP). Methods: Fifty-two patients (101 eyes) suffered from primary open-angle glaucoma with visual field defect and IOP less than 18mmHg were enrolled in this survey. The patients were randomly assigned to the therapeutic group (n = 53) and the control group (n = 48). Yiyanming solution 10 mL was administered orally three times per day for 12 weeks associated with the topical administration of in therapeutic group, and only was topically administered in the control group. The therapeutic effects of Yiyanming solution were assessed before treatment and at the end of the first, second, third month after treatment respectively. The changes of visual acuity, fundus and the mean defect (MD), mean sensitivity (MS) and loss vafiance (LV) of perimetry were observed. Written informed consent was obtained from the patients at the initial of this trial. Results: No obvious changes were found in visual acuity and fundus in all patients after administration of Yiyanming in both groups. In the 4th week after treatment, the MS value was significantly elevated (t = 4.009, P = 0.000), but the MD value was declined (t = -2.587, P = 0.013) in comparison with before treatment. In the 8th week after treatment, the MS value was considerably increased (t = 4.009, P = 0.000), but the MD and LV values were decreased (t = -3.374, P = 0.000; t = -2.868, P = 0.006) in comparison with before treatment in Yiyanming group. The rise of MS value, decline of MD and LV were statistically different after treatment versus before treatment (t = 5.086, P = 0.000; t = -2.580, P = 0.013; t = -2.765, P =0.008) at the 12nd week in the therapeutic group. Conclusion: Yiyanming oral solution may have protective effect on visual function of primary glaucoma with controlable IOP in some extent. LA: Chinese
Y. Wang. Department of Ophthalmology, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510120, China. wangyan96000@126.com
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
