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Abstract #28113 Published in IGR 13-1
Long-term effect of latanoprost on central corneal thickness in normal tension glaucoma
Kim HJ; Cho BJJournal of Ocular Pharmacology and Therapeutics 2011; 27: 73-76
Purpose: To evaluate the long-term effect of latanoprost on central corneal thickness (CCT) in patients with normal tension glaucoma (NTG). Methods: This was a retrospective study and included 166 eyes of 166 patients [128 with NTG and 38 with glaucoma suspect, suspicious discs with normal visual fields, and an intraocular pressure (IOP) (less-than or equal to)mmHg as the control group]. Patients with newly diagnosed NTG and who had not had previous topical glaucomatous treatment were followed (greater-than or equal to)24 months and received latanoprost 0.005% monotherapy once a day. CCT measurements were performed with an ultrasound pachymeter. CCT measurements before treatment and 24 months after treatment were analyzed. Results: There were no significant differences between the latanoprost group and the control group with respect to sex, age, baseline IOP, and CCT. A statistically significant reduction in the mean CCT was observed in the latanoprost group [535.5(plus or minus)37.9 vs. 530.1(plus or minus)36.4 (mu)m (n=128), P < 0.01], but not in the control group [543.1(plus or minus)40.2 vs. 542.6(plus or minus)37.0 (mu)m (n=38), P=0.786]. Conclusions: Long-term use of latanoprost may decrease the CCT in patients with NTG. Therefore, clinicians must be aware of longitudinal CCT variations that may arise throughout the follow-up period for proper IOP targeting and management.
B. J. Cho. Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, #4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, South Korea. bjcho@kuh.ac.kr
Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
11.4 Prostaglandins (Part of: 11 Medical treatment)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
