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Abstract #3451 Published in IGR 4-2
Morphologic features of degeneration and cell death in the neurosensory retina in dogs with primary angle-closure glaucoma
Whiteman AL; Klauss G; Miller PE; Dubielzig RRAmerican Journal of Veterinary Research 2002; 63: 257-261
OBJECTIVE: To investigate cellular death in the neurosensory portion of the retina during the first seven days after onset of clinical signs of overt primary angle-closure glaucoma (PACG) in dogs. SAMPLE POPULATION: Fourteen globes from dogs with PACG and two normotensive globes from dogs with PACG in the opposite eye. PROCEDURES: Retinas were examined via light microscopy and terminal deoxynucleotidyl transferase-mediated biotin-dUTP nick end-labelling. RESULTS: Necrosis of ganglion cells and segmental degeneration of the nerve fiber layer rapidly progressed to scattered full-thickness retinal attenuation and disorganization. Apoptosis was detectable within one day after onset of PACG and was prominent by three days. Necrosis of ganglion cells was significantly greater in retinas affected for ≤ 1 day, compared with retinas affected for > 1 day. In contrast, apoptosis in the ganglion cell layer was significantly greater in retinas affected for > 1 day, compared with retinas affected for ≤ 1 day. End-stage retinal atrophy was seen by day 7. CONCLUSIONS AND CLINICAL RELEVANCE: The presence of necrotic ganglion cells within one day after onset of clinical signs suggests a narrow window of opportunity to initiate effective therapy in overt PACG. Photoreceptor death is an important and striking aspect of neurosensory retinal degeneration after acute onset of PACG.
Dr. A.L. Whiteman, Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
Classification:
5 Experimental glaucoma; animal models
9.3.1 Acute primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)