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Abstract #3597 Published in IGR 4-2
Drug delivery systems to target the anterior segment of the eye: fundamental bases and clinical applications
Behar-Cohen FJournal Français d'Ophtalmologie 2002; 25: 537-544
The development of new drug delivery systems to target the anterior segment of the eye may offer many advantages, as follows: to increase the bioavailability of the drug, to allow penetration of a drug that cannot be used in solution form, to obtain constant and sustained drug release, to achieve higher local concentrations without systemic effects, to target one tissue or cell type more specifically, to reduce the frequency of instillation and therefore increase the compliance and comfort of the patient while reducing side-effects due to frequent instillation. Several approaches have been developed, which aim to increase the corneal contact time by modified formulation or reservoir systems, or by increasing tissue permeability using iontophoresis. To date, no ocular drug delivery system has been found to be ideal for all purposes. To maximize treatment efficacy, careful evaluation of the specific pathological condition, the targeted intraocular tissue, and the location of the most severe pathology must be made before selecting the method of delivery most suitable for each individual patient. LA: French
Dr. F. Behar-Cohen, INSERM U450, 15, rue de l'Ecole de medecine 75006 Paris, France
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
