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Abstract #3628 Published in IGR 4-2
Comparison of the effects of argon and neodymium:YAG laser iridotomy on cytokines in the rabbit aqueous humor
Er H; Doganay S; Evereklioglu C; Turkoz Y; Gunduz A; Borazan M; Ozyalin FEuropean Journal of Ophthalmology 2002; 12: 183-187
PURPOSE: The authors compared the effects in rabbits of iridotomy using the argon or Nd:YAG laser on cytokines such as interleukin 1-beta (IL-1β), interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor-alpha (TNF-α). METHODS: Twenty pigmented rabbits (20 eyes) underwent argon and Nd:YAG iridotomy under general and topical anesthesia. Group 1 (ten right eyes) was treated with the argon laser and group 2 (ten right eyes) with the Nd:YAG laser, using an equal number of shots and the same laser parameters for each group. Left eyes in both groups were evaluated as controls. Aqueous humor specimens were collected from each eye preoperatively and one and three days postoperatively. RESULTS: Aqueous IL-6 and TNF-α levels rose more on day 1 in the Nd:YAG group than the argon group. IL-6 and TNF-α levels were significantly higher on days 1 and 3 than the preoperative and control levels (p < 0.05). TNF-α levels on day 1 were significantly lower in the Nd:YAG than the argon group. There were no significant differences between the two laser groups for IL-6 on days 1 and 3. IL-1β and IL-8 did not change. CONCLUSIONS: These findings suggest that cytokines, particularly IL-6 and TNF-α, may be inflammatory mediators in the early inflammation following argon and Nd:YAG laser iridotomies. These results also indicate that cytokines contribute to the acute effects of Nd:YAG and argon laser applications on inflammation.
Dr. H. Er, Department of Ophthalmology, Inonu University School of Medicine, Turgut Ozal Medical Center, Malatya, Turkey. hamdier@inonu.edu.tr
Classification:
12.2 Laser iridotomy (Part of: 12 Surgical treatment)