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Abstract #3636 Published in IGR 4-2
An experimental study of inhibition of tetrandrine on posterior capsular opacification in rabbits
Guo L; Zhang X; Zhang SChinese Journal of Ophthalmology 2002; 38: 235-238
OBJECTIVE: To study the effect of tetrandrine (Tet) on the formation of posterior capsular opacification (PCO) after cataract extraction. METHODS: Intraocular lens implantation was performed on 48 healthy rabbit eyes, which were randomly divided into four groups: control (A), dexamethasone (B), Tet (C) and Tet with coated IOL (D). Dexamethasone and Tet were postoperatively injected into the subconjunctival space. The number of cells, the contents of protein and malondialdehyde (MDA) in the aqueous were determined on different days postoperatively. PCO was scored and opaque posterior capsules were weighed. RESULTS: The number of cells, amount of protein in the aqueous, scales and wet weight of PCO in the treated eyes were less than that of the control eyes (p < 0.05). In groups B and C, except for the 14th day content, the postoperative MDA was lower than that in the control group (p < 0.05). CONCLUSIONS: Tet can inhibit the formation of PCO, and has no obvious toxicity to the corneal endothelium. LA: Chinese
Dr. L. Guo, Ophthalmology Department, Henan Medical University, Zhengzhou 450056, China. drzs@263.net
Classification:
12.15 Capsulotomy (Part of: 12 Surgical treatment)
