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Abstract #46207 Published in IGR 13-2
Glaucoma medication and pregnancy: 11 cases
Noia G; Quattrocchi T; Visconti D; Caruso ABirth Defects Research Part A - Clinical and Molecular Teratology 2011; 91: 410
Introduction: The data about the effects of anti-glaucoma drugs during pregnancy are limited. The aim of this study was to observe pregnancies exposed to anti-glaucoma drugs. Methods: From January 2002 to December 2009 we recruited 11 women calling to our Teratology Information Service and we followed up by phone the women. Inclusion criteria were a topical dorzolamide therapy from preconception for glaucoma, and exclusion criteria was a comedication with prostaglandin analogues because some authors advise against these drugs use in pregnancy and other extra ocular comedications. The women called to our TIS in all period of pregnancy and they were informed of the lack of information in pregnancy about these medication, but they were counselled to continue their medication. Pregnancy and delivery complications, birth weight, congenital anomalies and psychophysical development of children up to eight years of age were evaluated. Results: A total of 11 women was evaluated: 4 had a monotherapy and 7 a politherapy (4 timolol, 1 fluorocinolon, 1 carbomer + timolol and 1 timolol + carbomer). The dosage varied from lgtt/day to 1 gtt three times day. The mean age of the patients was 31.18 years. They took glaucoma medication during all pregnancy, except two women that stopped their therapy during the first trimester instead of our counselling. One of these two woman stopped their therapy at the 6th weeks of pregnancy and for all the breastfeeding period and she developed blindness on the left eye. Average gestational week at the delivery was 38.4 weeks, average birth weight was 2994 gr and the ratio M/F was 0.8. Nine children were born without any congenital anomalies or low birth weight. Two pregnancies hesitated in spontaneous abortion during the first trimester. Conclusions: This preliminary study of eleven mothers taking topical glaucoma medications showed no adverse effects on pregnancy outcomes. It's important to recommend glaucoma treatment in pregnancy to avoid glaucoma complication.
G. Noia. Department of Obstetrics and Gynaecology, Teratology Information Service, Catholic University of Sacred Heart, Rome, Italy.
