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Abstract #46889 Published in IGR 13-3
Drug delivery to the posterior segment of the eye
Fischer N; Narayanan R; Loewenstein A; Kuppermann BDEuropean Journal of Ophthalmology 2011; 21: 20-26
Drug delivery into the posterior segment of the eye is complicated by the presence of the blood-ocular barrier. Strategies for delivering drugs to the posterior segment include systemic administration, modification of the blood-eye barrier, and local drug delivery. Recently, new topical treatments have emerged for the treatment of posterior eye disease. Iontophoretic, juxtascleral, and intravitreal routes can be used to achieve therapeutic levels in the posterior segment. Extended-release intravitreal drug delivery systems can achieve sustained therapeutic levels with the goal of providing a prolonged clinical benefit.
B. D. Kuppermann. Gavin Herbert Eye Institute, University of California, Department of Ophthalmology, Irvine 118 MedSurge I, Irvine, CA 92697, United States.
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
