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Abstract #47054 Published in IGR 13-3
End-to-end pipeline for spectral domain optical coherence tomography and morphometric analysis of human optic nerve head
Lee S; Young M; Sarunic MV; Beg MFJournal of Medical and Biological Engineering 2011; 31: 111-119
Glaucoma is an ocular neurodegenerative disease that causes progressive and irreversible loss of vision. Elevated intraocular pressure has been identified as a major risk factor; however, the significant variance among individual susceptibilities has not been fully understood. In histological studies of non-human primates, biomechanical changes in the optic nerve head (ONH) region due to intraocular pressure were found to be key determinants in the development and progression of the disease. Recent development in spectral-domain optical coherence tomography (SDOCT) allows non-invasive, three-dimensional (3D), high-resolution imaging of the ONH in vivo, which has also driven the development of computational tools to quantify the shape of the ONH in 3D and extract clinically meaningful information from the data. This report presents an end-to-end overview of an SDOCT imaging and morphometric analysis pipeline for human ONH. The system was designed to process a large number of SDOCT image volumes through a streamlined series of computational tools which are broadly divided into 4 modules: acquisition, processing, analysis, and visualization. During acquisition, SDOCT images are subject to motion artifacts caused by fixational eye movements, and an extended section is included to examine this issue and discuss various correction methods. A representative analysis on the optic cup morphometry is presented to demonstrate application of the pipeline. The goal of the system is to identify statistical trends in longitudinal and cross-sectional datasets, and ultimately to build comprehensive databases of ONH morphometrics which can serve as a basis for sensitive and accurate differentiation between normal and glaucomatous ONH, and for early detection of the disease to prevent irreversible vision loss.
M.F. Beg. School of Engineering Science, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
