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(15)

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Abstract #47671 Published in IGR 13-4

Effect on ocular blood flow of Combigan(registered trademark) versus placebo in patients with ocular hypertension

Puerto-Hernandez B; Rebolleda G; Garcia-Perez JL; Munoz-Negrete FJ; Gonzalez-Gordaliza C
Archivos de la Sociedad Española de Oftalmologia 2011; 86: 42-46

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Purpose: This study was undertaken to compare the ocular haemodynamic effects of Combigan(registered trademark) versus placebo in patients with ocular hypertension (OHT). Methods: Thirty patients with OHT were included in a controlled, randomised, double blind study in two parallel groups; 15 were randomised to receive Combigan(registered trademark) and 15 to receive placebo for a period of 3 months. At baseline and at 3 months retrobulbar blood flowmeasurements of the ophthalmic artery (OA) and central retinal artery (CRA) were taken using colour Doppler imaging(CDI) ultrasound, concurrently with intraocular pressure (IOP). Results: Combigan(registered trademark) significantly reduced IOP after 3 months of treatment (P = 0.001), whereas placebo showed no significant change in IOP. The baseline haemodynamic parameters were similar between treatment and placebo groups. Patients treated with Combigan(registered trademark) showed a statistically significant decrease in CRA resistive index (P = 0.007). Conclusions: Patients treated for 3 months with Combigan(registered trademark) showed a significant decrease of CRA resistive index that could be explained by the decrease in IOP. (copyright) 2010 Published by Elsevier Espana, S.L. on behalf of Sociedad Espanola de Oftalmologia. LA: Spanish

B. Puerto-Hernandez. Servicio de Oftalmologia, Unidad de Glaucoma, Hospital Ramon y Cajal, Madrid, Spain. Email: beapuertoh@hotmail.com

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Classification:

11.13.4 Betablocker and prostaglandin (Part of: 11 Medical treatment > 11.13 Combination therapy)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)

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