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Abstract #47817 Published in IGR 13-4
Age-related changes in the retinal nerve fiber layer of African American and caucasian healthy subjects using spectral domain optical coherence tomography
Buono K; Leite M; Bowd C; Weinreb R; Medeiros F; Zangwill LJournal of Investigative Medicine 2011; 59: 182
Purpose of Study: To evaluate the effect of aging and scan quality on spectral domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL) thickness in healthy participants of African descent (AD) and European descent (ED). Methods Used: AD (34 eyes) and ED (161 eyes) of 98 healthy participants from the UCSD Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Evaluation Study (ADAGES) underwent RNFL imaging with Cirrus SDOCT (Carl Zeiss Meditec, Inc, Dublin, CA). AD (30 eyes) and ED (120 eyes) of 75 healthy participants who underwent RNFL imaging with Cirrus SDOCT also underwent RNFL imaging with Spectralis SDOCT (Heidelberg Engineering, Inc, Heidelberg, Germany). Univariable and multivariable analysis of the effect of age, SDOCT quality score, race, disc size and axial length on RNFL thickness was completed. Summary of Results: There was significant (p<0.05) thinning with increasing age for the inferior Cirrus RNFL sector and the global, inferotemporal, and inferonasal Spectralis RNFL sectors. There was also significant RNFL thinning with a poorer quality score for all of the Cirrus RNFL sectors and for the temporal and superotemporal Spectralis RNFL sectors. The effect of age and quality score was similar in AD and ED eyes and explained approximately 20% and 7%, respectively of the variation in the univariable models of the inferior RNFL quadrant. Conclusions: AD and ED eyes demonstrated age-related thinning of the RNFL in the inferior quadrant, which is a location that is often affected early in glaucoma disease progression. These results suggest that SDOCT shows promise in providing quantitative data about the extent of age-related changes in the RNFL of healthy eyes. Due to the observation that the SDOCT quality score affects the RNFL measurement, future studies will need to account for this relationship in order to ensure that measured RNFL changes in healthy eyes are due to changes in age alone rather than changes in age-related SDOCT quality scores.
K. Buono. Federal University of Sao Paulo, Sao Paulo, Brazil.
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
