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Abstract #47838 Published in IGR 13-4
Visual field evolution in glaucoma patients presenting with different disease stages: Results from an observational study
Gerlier L; Shlaen R; Wolfram C; Lamotte M; Verboven YValue in Health 2011; 14: A502-A503
OBJECTIVES: The progression of glaucoma is measured by a Mean Defect (MD) of the perimetry in decibels (db), from an early disease stage (<6db loss), until moderate (6-12db loss), advanced stages (12-24db loss) and eventually blindness (>24db loss). The rate of disease progression is highly variable between individuals and hard to predict. The objective of this study was to analyze the change in MD of glaucoma patients in a real-life setting in Germany. METHODS: We analyzed patient- level data from a German observational study in ocular hypertension (OHT) and glaucoma, with retrospective collection of MD measures (db). Descriptive statistics were derived on the rate of disease progression (db loss/year, obtained by dividing the change in MD by the duration of observation). The change in MD in best eye between the time of first treatment until last MD measure was included in a generalized linear regression, adjusting for age, sex, presence of cataract, time since first treatment, initialMDand initial glaucoma stage (OHT, early/moderate or advanced). RESULTS: MD data was available for 57 patients (53% female, mean age 67 +/-12 years). The mean (SD) time from first treatment until last MD measure was 7.0 (3.7) years. The mean (SD) MD was -4.5db (4.7) at first treatment and -6.0db (6.8) at last assessment (i.e. average rate of progression of -0.21db/year, all stages). In 12 OHT patients, 50% had no MD worsening, while 50% lost on average -0.26db/ year. Based on the adjusted analysis, the initial diagnosis was significantly associated with the amount of db loss over time (early/moderate glaucoma -0.19db/year +/-0.13, advanced -0.66db/year +/-0.22, p=0.038). CONCLUSIONS: The rates of disease progression measured over more than 7 years in glaucoma patients was significantly increasing with their initial disease severity. Amount of db loss per year were in line with previously published prospective studies.
L. Gerlier. IMS Consulting Group, Vilvoorde, Belgium.
Classification:
6.20 Progression (Part of: 6 Clinical examination methods)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
