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Abstract #47947 Published in IGR 13-4
Polyamidoamine dendrimer hydrogel for enhanced delivery of antiglaucoma drugs
Holden CA; Tyagi P; Thakur A; Kadam R; Jadhav G; Kompella UB; Yang HNanomedicine: Nanotechnology, Biology, and Medicine 2011;
Dendrimer hydrogel (DH), made from ultraviolet-cured polyamidoamine dendrimer G3.0 tethered with three polyethylene glycol (PEG, 12,000 Da)-acrylate chains (8.1% w/v) in pH 7.4 phosphate buffered saline (PBS), was studied for the delivery of brimonidine (0.1% w/v) and timolol maleate (0.5% w/v), two antiglaucoma drugs. DH was found to be mucoadhesive to mucin particles and nontoxic to human corneal epithelial cells. DH increased the PBS solubility of brimonidine by 77.6% and sustained the in vitro release of both drugs over 56-72 hours. As compared to eye drop formulations (PBS-drug solutions), DH brought about substantially higher human corneal epithelial cells uptake and significantly increased bovine corneal transport for both drugs. DH increased timolol maleate uptake in bovine corneal epithelium, stroma, and endothelium by 0.4- to 4.6-fold. This work demonstrated that DH can enhance the delivery of antiglaucoma drugs in multiple aspects and represents a novel platform for ocular drug delivery. (copyright) 2011 Elsevier Inc. All rights reserved.
H. Yang. Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richm, . Email: hyang2@vcu.edu
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
