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Abstract #48086 Published in IGR 13-4
Differences in baseline dark and dark-light changes of anterior chamber angle parameters among whites and ethnic Chinese
Wang D; Chiu C; He M; Wu L; Kao A; Lin SInvestigative Ophthalmology and Visual Science 2011; 9404-9410
PURPOSE: To assess the drainage angle width in dark and dark-light change (Δ) between Caucasians and Chinese aged 40 years and over. METHODS: Study groups were comprised of four age- and gender-matched cohorts: American Caucasians, American Chinese, southern mainland Chinese and northern mainland Chinese. Anterior segment optical coherence tomography (ASOCT) images of the anterior chamber angles were obtained under both light and dark conditions. Parameters analyzed included angle opening distance (AOD), angle recess area (ARA) and trabecular iris space area (TISA). RESULTS: Data from 121, 124, 121, and 120 participants were obtained who were American Caucasians, American Chinese, and southern and northern mainland Chinese, respectively. In multiple linear regression analysis, adjusting for age, gender, refractive status, pupil size, lens location, anterior chamber depth (ACD) and width (ACW), ethnic Chinese had significantly smaller ARA (regression coefficient, β=-0.06, P<0.001) and TISA (β=-0.01, P=0.039), as well as greater ΔAOD (β=0.03, P=0.009) and ΔTISA (β=0.02, P=0.029) than Caucasians. For the dark-light change analysis, the independent associations between angle width and iris thickness (IT) and iris curvature (ICurv) were only identified in Chinese. CONCLUSIONS: Compared with Caucasians, ethnic Chinese had smaller ARA and TISA yet greater dark-light change of AOD and TISA, independent of refractive status and overall ocular anterior segment dimensions.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, P.R. China.
Classification:
2.4 Anterior chamber angle (Part of: 2 Anatomical structures in glaucoma)
6.13 Provocative tests (Part of: 6 Clinical examination methods)
