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Abstract #48098 Published in IGR 13-4
Comparative Human Aqueous Dynamics Study between Black and White Subjects with Glaucoma
Beltran-Agullo L; Alaghband P; Rashid S; Gosselin J; Obi A; Husain R; Lim KSInvestigative Ophthalmology and Visual Science 2011; 52: 9425-9430
PURPOSE: To compare the baseline aqueous humor dynamics in white Caucasian and patients of African origin with previously untreated primary open angle glaucoma (POAG) or ocular hypertension (OHT).METHODS:Ninety-one participants were enrolled in this prospective, observational controlled study: 34 black subjects with POAG or OHT, 32 white Caucasian participants with POAG or OHT, 12 black and 13 white healthy volunteers as controls. All aqueous humor parameters were taken between 9am and 12pm on a same day. Intraocular pressure (IOP) was measured by pneumatonometer; morning aqueous humor flow rate was measured by fluorophotometry and trabecular outflow facility by electronic Schiøtz tonography. Uveoscleral outflow was calculated using the Goldmann's equation with assumed episcleral venous pressure of 8, 9, 10 and 11mmHg. Differences among groups were analyzed by using parametric and non parametric tests and relationship between aqueous dynamics parameters were evaluated using linear regression analyses. RESULTS: The POAG/OHT groups had similar IOP (white, 24.6±3.0mmHg; black 24.3±4.0mmHg; P(HBonf)=0.51), outflow facility (white, 0.13±0.09μl/min/mmHg; black 0.13±0.07μl/min/mmHg; P(HBonf)=0.87), aqueous flow (white, 2.36±0.63μl/min; black 2.35±0.53μl/min; P(HBonf)=0.95) and uveoscleral outflow (white, 0.42±1.59μl/min; black, 0.58±1.17μl/min; P(HBonf)=1.78). POAG/OHT groups had significantly higher IOP and lower outflow facility than their healthy counterparts (p<0.01). Black participants had significant thinner corneas (540±37μm vs 564±36μm) than white participants (P=0.002).CONCLUSIONS:The aqueous humor dynamics of black African and white Caucasian patients with POAG or OHT have no significant differences. However, the significantly thinner corneas of the black patients might be masking potential differences in outflow facility and IOP measurements between the racial groups.
Department of Ophthalmology, St Thomas' Hospital, London, UK.
Classification:
2.6.1 Production (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)
2.6.2.1 Trabecular meshwork (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics > 2.6.2 Outflow)
2.6.2.2 Uveoscleral (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics > 2.6.2 Outflow)
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
