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Abstract #49061 Published in IGR 14-1
The 'structure-function' relationship in glaucoma: past thinking and current concepts - a review
Malik R; Swanson WH; Garway-Heath DFClinical and Experimental Ophthalmology 2012; 40: 369-380
An understanding of the relationship between functional and structural measures in primary open angle glaucoma (POAG) is necessary for both grading the severity of disease and for understanding the natural history of the condition. This article outlines the current evidence for the nature of this relationship, and highlights the current mathematical models linking structure and function. Large clinical trials demonstrate that both structural and functional change are apparent in advanced stages of disease, while, at an individual level, detectable structural abnormality may precede functional abnormality in some patients whilst the converse in true in other patients. Although the exact nature of the 'structure-function' relationship in POAG is still the topic of scientific debate and the subject of continuing research, this article aims to provide the clinician with an understanding of the past concepts and contemporary thinking in relation to the structure-function relationship in POAG. © 2012 The Authors. Journal compilation © 2012 Royal Australian and New Zealand College of Ophthalmologists.
NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom Indiana University School of Optometry, Bloomington, Indiana, USA.
Full articleClassification:
1.3 Pathogenesis (Part of: 1 General aspects)
15 Miscellaneous
