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Abstract #49091 Published in IGR 14-1

Definition of glaucoma: clinical and experimental concepts

Casson RJ; Chidlow G; Wood JP; Crowston JG; Goldberg I
Clinical and Experimental Ophthalmology 2012; 40: 341-349


Glaucoma is a term describing a group of ocular disorders with multi-factorial aetiology united by a clinically characteristic intraocular pressure-associated optic neuropathy. It is not a single entity and is sometimes referred to in the plural as the glaucomas. All forms are potentially progressive and can lead to blindness. The diverse conditions that comprise glaucoma are united by a clinically characteristic optic neuropathy, known as glaucomatous optic neuropathy (GON). Evidence suggests that the primary site of neurological injury is at the optic nerve head (ONH). This single fact, sometimes conceptualized as common end-organ damage, enables the conditions to be grouped, irrespective of the causal mechanism(s). The term experimental glaucoma implies model resemblance to the human condition. We propose that "experimental glaucoma" be restricted to animal models with demonstrable features of GON and/or evidence of a primary axonopathy at the ONH. A fundamental inadequacy in this framework is any reference to the pathogenesis of GON, which remains unclear. © 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.

South Australian Institute of Ophthalmology, Hanson Institute & Adelaide University, Adelaide Centre for Eye Research Australia & University of Melbourne, Melbourne, Eye Associates, Glaucoma Services, Sydney Eye Hospital, University of Sydney, Sydney, Australia.

Full article

Classification:

15 Miscellaneous
5.2 Primates (Part of: 5 Experimental glaucoma; animal models)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)



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