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Abstract #49157 Published in IGR 14-1
Damping of intraocular pressure fluctuations
Cringle SJ; Yu DYClinical and Experimental Ophthalmology 2012; 40: 881-887
BACKGROUND: There is increasing evidence that relatively rapid spikes in intraocular pressure (IOP) may contribute to axonal damage in glaucoma. The present study seeks to quantify the ability of a compressible damping element (a simple air bubble) to reduce intraocular IOP fluctuations induced by a known change in intraocular fluid volume. METHODS: A mathematical model describing the damping of IOP increases for a given infusion volume was developed and compared with experimental data obtained from isolated pig eyes. A damping element (100 µL to 2 mL of air) was added to the system and the effect on the induced IOP change for a given infusion volume was assessed. RESULTS: The introduction of the damping element reduced the IOP change in a volume dependent manner consistent with the mathematical modelling. The maximum bubble size tested (2 mL) dampened the IOP change by an average of 63.5 + 8.7 % at a baseline pressure close to 20 mmHg. Close agreement was seen between the mathematical model and the experimental data. CONCLUSION: Mathematical modelling and experiments in isolated pig eyes demonstrated that the addition of a damping element in the form of a compressible air bubble is capable of significantly reducing induced IOP spikes.
Centre for Ophthalmology and Visual Science and the ARC Centre of Excellence in Vision Science, The University of Western Australia, Perth, Australia.
Full articleClassification:
6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
