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Abstract #49289 Published in IGR 14-1
Factors associated with anterior chamber narrowing with age: an optical coherence tomography study
Sun JH; Sung KR; Yun SC; Cheon MH; Tchah H; Kim MJ; Kim JYInvestigative Ophthalmology and Visual Science 2012; 53: 2607-2610
PURPOSE: To evaluate the effect of age on various anterior segment (AS) parameters in healthy eyes using AS optical coherence tomography (OCT), and to examine their relationship to anterior chamber angle (ACA) narrowing with age. METHODS: Three hundred-and-eighty-eight consecutive Korean subjects aged 30 to 89 years were imaged by AS OCT (Visante, version 2.0; Carl Zeiss Meditec, Dublin, CA). Anterior chamber depth (ACD), iris cross-sectional area (IA), iris thickness at 750 and 1,500 microns from the scleral spur (IT750, 1500), iris curvature (IC), lens vault (LV), and anterior chamber area (AA) were determined using Image J software (version 1.44). The absolute and normalized slopes of these parameters, adjusted for axial length and gender were determined by linear mixed-effects modeling. Multivariate regression analysis was performed to evaluate factors associated with ACA narrowing, which was defined as the angle-opening distance (AOD 500) at the temporal angle. RESULTS: ACD and AA had significantly negative slopes (-0.0119mm/year, -0.0845mm2/year, p < 0.0001, <0.0001) with age, and LV, IC, IT750, 1500, and IA had significantly positive slopes (0.0084, 0.0019, 0.0006, 0.0008, 0.0131; all, P<0.05). IC, ACD, LV and AA underwent the greatest changes when analyzed by normalized slopes. IC, LV, age and axial length were significantly associated with ACA narrowing (all, P<0.0001). CONCLUSIONS: Increments of LV, IC, IT and IA with age led to a reduction in the dimensions of the AC and to narrowing of the ACA. This may explain why aging is a significant risk factor for primary angle closure glaucoma.
Ophthalmology, Asan Medical Center, University of Ulsan, College of Ulsan, Ophthalmology, Seoul, Korea (South).
Full articleClassification:
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
2.4 Anterior chamber angle (Part of: 2 Anatomical structures in glaucoma)
