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Abstract #50396 Published in IGR 14-2
Is primary open angle glaucoma part of a generalised sensory neurodegeneration? A review of the evidence
O'Hare F; Rance G; McKendrick AM; Crowston JGClinical and Experimental Ophthalmology 2012; 40: 895-905
Open angle glaucoma is an optic neuropathy that has a multifarious aetiological profile. Emerging theories suggest that a group of factors induce optic nerve injury in innately susceptible aging optic nerves. These factors have the potential to impact on the function of other vulnerable neurons within the central nervous system of older patients. Although changes within the visual pathways due to retinal ganglion cell dysfunction and death are well established, research exploring the behaviour of other sensory systems in individuals with glaucoma is limited. This review summarises what is known about these other non-visual sensory changes, explores whether glaucoma is in fact part of a global neurodegenerative condition, and suggests areas for future research direction. © 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia Royal Victorian Eye & Ear Hospital, Victoria, Australia Department of Audiology & Otolaryngology, University of Melbourne, Victoria, Australia. Department of Optometry & Vision Sciences, University of Melbourne, Victoria, Australia.
Full articleClassification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
