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Abstract #50461 Published in IGR 14-2
Comparison of long-term variability of retinal nerve fiber layer measurements made with the RTVue OCT and scanning laser polarimetry
Naghizadeh F; Garas A; Vargha P; Holló; GEuropean Journal of Ophthalmology 2012; 0: 0
PURPOSE: To compare long-term variability of retinal nerve fiber layer thickness (RNFLT) measurements made with the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) and enhanced (GDx-ECC) corneal compensation. METHODS: One eye each of 110 Caucasian patients (17 healthy, 20 ocular hypertensive, 22 preperimetric, and 51 perimetric glaucoma eyes, of which 10 showed visual field progression) were imaged prospectively at 6-month intervals for 1.5 to 3 years. RESULTS: Median change of Octopus visual field mean defect was -0.300 dB/y for the controls, -0.120 dB/y for perimetric glaucoma group, and 1.231 dB/y for the 10 functionally progressing perimetric glaucoma eyes. Relative (%) variance of all RNFLT parameters measured with RTVue-OCT was significantly (p<0.001) smaller than that with both of the GDx methods. Relative RNFLT progression slopes (% change/y) did not differ significantly between the methods. Relative variance of the RNFLT parameters did not differ between the control and perimetric glaucoma group with RTVue-OCT, but for most parameters it was consistently higher for perimetric glaucoma with both GDx methods (p=0.01). Relative RNFLT progression slopes, however, did not separate the control and perimetric glaucoma eyes with either method. CONCLUSIONS: Long-term RNFLT measurements are less variable with the RTVue-OCT than with GDx-VCC and GDx-ECC. Long-term measurement variability is higher in perimetric glaucoma than in healthy eyes with both GDx methods, but no similar between-group difference is seen with RTvue-OCT. None of the tested methods separated the rate of progression between healthy and well-controlled perimetric glaucoma eyes in 1.5 to 3 years follow-up.
Department of Ophthalmology, Semmelweis University, Budapest - Hungary.
Full articleClassification:
6.9.1.2 Confocal Scanning Laser Polarimetry (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
