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Abstract #50570 Published in IGR 14-2
Extended drug delivery by contact lenses for glaucoma therapy
Peng CC; Burke MT; Carbia BE; Plummer C; Chauhan AJournal of Controlled Release 2012; 162: 152-158
We combine laboratory-based timolol release studies and in vivo pharmacodynamics studies in beagle dogs to evaluate the efficacy of glaucoma therapy through extended wear contact lenses. Commercial contact lenses cannot provide extended delivery of ophthalmic drugs and so the studies here focused on increasing the release duration of timolol from ACUVUE® TruEye™ contact lenses by incorporating vitamin E diffusion barriers. The efficacy of timolol delivered via extended wear contact lenses was then compared to eye drops in beagle dogs that suffer from spontaneous glaucoma. The lenses were either replaced every 24h or continuously worn for 4days, and the pharmacodynamics effect of changes in the intraocular pressure (IOP) of timolol from the ACUVUE® TruEye™ contact lenses can be significantly increased by incorporation of vitamin E. The in vivo studies showed that IOP reduction from baseline by pure contact lens on daily basis was comparable with that by eye drops but with only 20% of drug dose, which suggested higher drug bioavailability for contact lenses. In addition, by inclusion of vitamin E into the lenses, the IOP was reduced significantly during the 4-day treatment with continuous wear of lens.
Chemical Engineering, University of Florida, Gainesville, FL 32611, United States.
Full articleClassification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.13.4 Betablocker and prostaglandin (Part of: 11 Medical treatment > 11.13 Combination therapy)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
