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Abstract #50971 Published in IGR 14-3
Reduced white matter integrity in primary open-angle glaucoma: A DTI study using tract-based spatial statistics
Lu P; Shi L; Du H; Xie B; Li C; Li S; Liu T; Feng H; Wang JJournal of neuroradiology. Journal de neuroradiologie 2013; 40: 89-93
BACKGROUND AND PURPOSE: The present study was designed to map the alteration of white matter in primary open-angle glaucoma (POAG) by applying tract-based spatial statistics (TBSS) analysis. METHODS: Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE). RESULTS: Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p<0.05, corrected). CONCLUSION: The change in white-matter FA may indicate atrophy of the visual cortex that may be important in the diagnosis and treatment of POAG patients.
Department of Neurosurgery, Jinan Military General Hospital, Jinan 250000, PR China.
Full articleClassification:
2.16 Chiasma and retrochiasmal central nervous system (Part of: 2 Anatomical structures in glaucoma)
6.30 Other (Part of: 6 Clinical examination methods)
