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Abstract #51169 Published in IGR 14-3
Detection of Early Glaucomatous Progression With Different Parameters of the RTVue Optical Coherence Tomograph
Naghizadeh F; Garas A; Vargha P; Holló GJournal of Glaucoma 2014; 23: 195-198
PURPOSE: To investigate the ability of different parameters of the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-OCT) to detect early glaucomatous progression. METHODS: One eye of 17 healthy and 51 perimetric glaucoma patients was imaged prospectively at 6-month intervals for 1.5 to 3 years. Progression was determined by Octopus normal G2 visual field progression criteria. RESULTS: Ten of the 51 glaucoma eyes progressed based on visual field criteria. Median visual field mean defect change was -0.300 dB/y for the controls, -0.120 dB/y for all glaucoma eyes (P=0.461 vs. controls), and 1.231 dB/y for the 10 functionally progressing glaucoma eyes (P<0.001 vs. controls). Ganglion cell complex (GCC), focal loss volume, and GCC global loss volume showed significantly faster rate of progression in the glaucoma group than in controls (P=0.004 and P=0.001, respectively). No optic nerve head, retinal nerve fiber layer thickness, and average GCC parameter separated the rate of progression between the groups. CONCLUSIONS: Early structural progression of glaucoma may be better detected with pattern-based GCC parameters of the RTVue-OCT than with the optic nerve head, retinal nerve fiber layer thickness or average GCC parameters of the same instrument.
*Department of Ophthalmology †Cardiovascular Center, Semmelweis University, Budapest, Hungary.
Full articleClassification:
6.20 Progression (Part of: 6 Clinical examination methods)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
