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BACKGROUND: The water drinking test (WDT) has been used as a surrogate for detecting patients who have intraocular pressure (IOP) spikes not identified during office hours or as a stress test to evaluate the drainage system of the eye. However, in order to be clinically applicable, a test must provide reproducible results with consistent measurements. This study was performed to verify the reproducibility of IOP peaks and fluctuation detected during the WDT in patients with ocular hypertension (OH) and open-angle glaucoma (OAG). DESIGN: a prospective analysis of patients in a tertiary care unit for glaucoma treatment. PARTICIPANTS: 24 OH and 64 OAG patients not under treatment. METHODS: The WDT was performed in two consecutive days by the same examiners in patients not under treatment. Reproducibility was assessed using the intraclass correlation coefficient (ICC). MAIN OUTCOME MEASURES: Peak and Fluctuation of IOP obtained with the WDT were analyzed for reproducibility. RESULTS: 88 eyes from 24 OH and 64 OAG patients not under treatment were evaluated. Test and retest IOP peak values were 28.38+4.64 and 28.38+4.56 mmHg respectively (p=1.00). Test and retest IOP fluctuation values were 5.75+3.9 and 4.99+2.7 mmHg, respectively (p=0.06). Based on intraclass coefficient, reproducibility was excellent for peak IOP (ICC=0.79) and fair for IOP fluctuation (ICC=0.37). CONCLUSION: IOP peaks detected during the WDT presented excellent reproducibility, whereas the reproducibility of fluctuation was considered fair.
University of São Paulo School of Medicine, Av. Dr. Enéas Carvalho de Aguiar, 255 Cerqueira César, São, Paulo, SP, Brazil.
Full article6.13 Provocative tests (Part of: 6 Clinical examination methods)