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Abstract #53085 Published in IGR 15-1
Review: Epigenetic mechanisms in ocular disease
He S; Li X; Chan N; Hinton DRMolecular Vision 2013; 19: 665-674
Epigenetics has become an increasingly important area of biomedical research. Increasing evidence shows that epigenetic alterations influence common pathologic responses including inflammation, ischemia, neoplasia, aging, and neurodegeneration. Importantly, epigenetic mechanisms may have a pathogenic role in many complex eye diseases such as corneal dystrophy, cataract, glaucoma, diabetic retinopathy, ocular neoplasia, uveitis, and age-related macular degeneration. The emerging emphasis on epigenetic mechanisms in studies of eye disease may provide new insights into the pathogenesis of complex eye diseases and aid in the development of novel treatments for these diseases.
Department of Pathology, Keck School of Medicine of the University of Southern CA, USA.
Classification:
3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)
1.3 Pathogenesis (Part of: 1 General aspects)
