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Abstract #5364 Published in IGR 1-2
Increased nitric oxide levels in aqueous humor of diabetic patients with neovascular glaucoma (letter)
Chiou SH; Chang CJ; Chou CK; Hsu WM; Liu JH; Chiang CHDiabetes Care 1999; 22: 861-862
The most common cause of neovascular glaucoma is diabetes. Vascular endothelial growth factor plays a key role in the pathophysiology of neovascular glaucoma and increases cytolic calcium to promote calmodulin binding on the endothelium isoform of nitric oxide synthase and stimulate nitric oxide production. These authors analyzed the nitric oxide level in the aqueous humor of diabetic patients with neovascular glaucoma. They found that the nitric oxide levels were significantly higher in diabetes with neovascular glaucoma than in diabetes with proliferative or non-proliferative diabetic retinopathy. It was higher in all diabetic patients than in patients with cataracts but without diabetes. They feel that control of nitric oxide levels in the eye may be a target in preventing angiogenesis in neovascular glaucoma.
Classification:
9.4.5.1 Neovascular glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)
