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Abstract #54342 Published in IGR 15-3
Adjustment of the retinal angle in SD-OCT of glaucomatous eyes provides better intervisit reproducibility of peripapillary RNFL thickness
Lee K; Sonka M; Kwon YH; Garvin MK; Abrà,moff MDInvestigative Ophthalmology and Visual Science 2013; 54: 4808-4812
PURPOSE: To report an automated method for adjustment of the retinal angle in spectral-domain optical coherence tomography (SD-OCT) and compare its intervisit reproducibility of the peripapillary retinal nerve fiber layer (RNFL) thicknesses of glaucomatous eyes to that obtained by the Cirrus algorithm. METHODS: Fifty-six glaucoma and glaucoma suspect subjects were repeatedly imaged, and optic nerve head (ONH)-centered OCT image volumes (200×200×1024 voxels, 6×6×2 mm3, Cirrus HD-OCT machine) were acquired within a 4-month period from one eye of the 56 patients. Retinal angle correction in B-scans was accomplished by adjusting the angle using the voxel aspect ratio of the SD-OCT followed by straightening of rotated A-scans. The RNFL layer was automatically segmented using the Iowa Reference Algorithm. Reproducibility of the peripapillary RNFL thicknesses was determined by intraclass correlation coefficient (ICC), coefficient of variation (CV), repeatability coefficient (RC), and 95% tolerance limit (TL) for the Iowa Reference Algorithm without and with the retinal angle correction and for the Cirrus algorithm (Cirrus version 5.1.0.96). RESULTS: The angle corrected Iowa Reference Algorithm (ICC: 0.990, 95% confidence interval [CI]: 0.983-0.994) for peripapillary RNFL thicknesses showed significantly better reproducibility than the nonangle corrected algorithm (ICC: 0.964, 95% CI: 0.940-0.979) and the Cirrus algorithm (ICC: 0.960, 95% CI: 0.933-0.976) based on the 95% CIs for the ICCs. CONCLUSIONS: Angle correction leads to more consistent peripapillary RNFL thicknesses. This may lead to improved management of patients with glaucoma.
Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa 52242, USA.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)