advertisement
Abstract #5492 Published in IGR 1-2
The effect of cyclosporin A on cultured rabbit subconjunctival fibroblast proliferation
Bacia G; Yücelb C; Duranolub YOphthalmologica 1999; 213: 114-119
The aim of this study was to examine the possible effects of local application of a potent immunosuppressive drug, cyclosporin A (CsA), on fibroblast proliferation in vitro. Rabbit subconjunctival fibroblasts were cultured and incubated with varying doses of CsA (from 0.5-5%). Growth inhibition curves were obtained, and cell attachment and reversibility of drug-induced growth inhibition were studied. None of the doses stimulated fibroblast proliferation. CsA inhibited fibroblast proliferation depending on the dose and duration of application. Also, drug-induced growth inhibition decreased depending on dose and duration of application. While the dosage which led to 50% inhibition was found to be 7.2 mg/ml, 4% and higher doses had toxic effects.
G. Bacia, Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya; Turkey
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)