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Abstract #55191 Published in IGR 15-4
Understanding the causation of primary angle closure disease using the sufficient component cause model
Ravi TR; Mengersen K; Thomas A; Walland MJClinical and Experimental Ophthalmology 2014; 42: 522-528
BACKGROUND: Several risk factors have been associated with primary angle closure disease (PACD) but their actual role in causation of an individual case is not clear. DESIGN: Concept paper PARTICIPANTS/SAMPLES: No patient participation METHODS: The sufficient component cause model is briefly explained in the context of PACD. The framework is used to conceptualize the role of individual mechanisms of disease. The possibility of personalized treatment for PACD is discussed in this context. MAIN OUTCOME MEASURES: Qualitative concepts in disease causality may refine research and treatment in PACD. RESULTS: The minimum set of conditions that are sufficient for PACD to occur is considered the sufficient component cause model for that individual case. Described risk factors (including genes) as well as currently unknown influences play a role in the model. There may be many such models and all complementary components in any sufficient-cause model must be present for disease to occur. Interruption of any one component in that model can be used for treatment. Pupillary block is likely a component of most such models and may currently be considered a universally necessary component of these models. CONCLUSIONS: The sufficient component cause model can be used as a framework to explain the role of individual mechanisms of causation and treatment of PACD. It also aids understanding of the proportion of disease due to specific causes.
Full article
Classification:
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
