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Abstract #5769 Published in IGR 2-1
Progressive optic nerve cupping and neural rim decrease in a patient with bilateral autosomal dominant optic nerve colobomas
Moore M; Salles D; Jampol LEAmerican Journal of Ophthalmology 2000; 129: 517-520
PURPOSE: To document progressive optic nerve cupping and neural rim decrease in a patient with normal intraocular pressures and bilateral autosomal dominant optic nerve colobomas. METHODS: The ophthalmology records, stereoscopic fundus photographs, and visual fields of a 27-year-old woman with familial (autosomal dominant) optic nerve colobomas were reviewed. The appearance of the optic nerves was documented over a 13-year period (1985-1998). RESULTS: Despite repeatedly normal intraocular pressures, the patient showed progressive optic nerve cupping and neural rim decrease in both eyes. Visual field testing was available over a five-year period (1993-1998) and was abnormal, but no progression was seen. CONCLUSIONS: This case of progressive cupping and neural rim decrease in a patient with autosomal dominant optic nerve coloboma in both eyes may provide insight into the optic nerve cupping associated with normal tension glaucoma. Careful follow-up of patients with optic disc colobomas is indicated to detect possible optic nerve changes or field loss.
Dr. L.M. Jampol, Department of Ophthalmology, 645 North Michigan Avenue, #440, Chicago, IL 60611, USA. l-jampol@nwu.edu
Classification:
10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy
