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Abstract #59251 Published in IGR 16-3

LOXL1-associated candidate epithelial pathomechanisms in exfoliation glaucoma

Laczko R; Szauter KM; Csiszar K
Journal of Glaucoma 2014; 23: S43-7

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RESULTS: of the present study support ocular epithelia-specific LOXL1 functions in exfoliation glaucoma that may include both dysregulated extracellular matrix cross-linking activity and cellular mechanisms involving a role for LOXL1, in direct interaction with Snail1, in promoting epithelial to mesenchymal transition and a potential shift towards fibrogenic epithelial cell phenotypes.

John A. Burns School of Medicine, University of Hawaii, Honolulu, HI.

Full article

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Classification:

9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
3.6 Cellular biology (Part of: 3 Laboratory methods)

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