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Abstract #6102 Published in IGR 2-2
Dysgenetic changes in the chamber angle in patients with glaucoma or in glaucoma suspects developed before the age of 40 years
Kniestedt C; Kammann MTT; Sturmer J; Gloor BPKlinische Monatsblätter für Augenheilkunde 2000; 216: 377-387
OBJECTIVE: The aim of this study was to determine percentage and degree of dysgenetic changes in the chamber angle of glaucoma suspects and in patients who acquired glaucoma before the age of 40 years, and to compare the primary classification with the classification after re-examination. PATIENTS AND METHODS: Two hundred eyes of 104 patients (59 males, 45 females, 0-40 years (median, 29) at the time of detection) were examined or re-examinded by gonioscopy and photography with the CGA-1 goniolens. The angles were documented by drawing and by goniophotography. The different features of dysgenesis served to establish a point-scale. RESULTS: Of 200 eyes, in 24 eyes (12%) a slight, in 81 (40,5%) an indermediate, and in 49 (24.5%) a severe goniodysgenesis was found. On re-examination the dysgenesis rate rose from 48-77%. CONCLUSIONS: The high frequency of dysgenetic changes in the chamber angle of glaucoma patients affected before the age of 40 years suggests that in this age group developmental glaucoma is predominant and has to be separated from POAG as a special entity. Two questions arise: 1. Were these dysgenetic changes overlooked most of the time in the newer genetic studies of patients with GLC1A, or, if not, 2. Do glaucoma suspects and patients with open-angle glaucomas before the age of 40 years, with and without dysgenetic changes, belong to groups with different glaucoma genes, the 'with' to genes IRID 1 and IRID 2 and the 'without' to genes GLC1A to GLC1F?LA: German
Dr. C. Kniestedt, Augenklinik des Universität Zurich, 8091 Zurich, Switzerland
Classification:
9.1.3 Syndromes of Axenfeld, Rieger, Peters, aniridia (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
