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Abstract #6162 Published in IGR 2-2
MRI of the intraorbital optic nerve in patients with autosomal dominant optic atrophy
Votruba M; Leary S; Losseff N; Bhattacharya SS; Moore AT; Miller DH; Moseley IFNeuroradiology 2000; 42: 180-183
Measurements of the intraorbital optic nerve were made using high-resolution coronal MRI in ten adults with autosomal dominant optic atrophy. Comparisons were made with previous studies of ten normal adult subjects. The cross-sectional diameters of the optic nerve and the perineural subarachnoid space were measured and a ratio of there diameters at anterior, mid and posterior positions along the optic nerve was determined. The authors found a statistically significant difference in the mean optic nerve: sheath ratio between the control group and patients with autosomal dominant optic atrophy. At anterior, mid and posterior locations along the optic nerve it is significantly smaller in patients with optic atrophy. They have demonstrated that the loss of ganglion cells, previously documented in dominant optic atrophy, is associated with a significant loss of optic nerve tissue and thinning of the nerve along its length.
Dr. M. Votruba, Department of Molecular Genetics, Institute of Ophthalmology, London, UK. mvotruba@hgmp.mrc.ac.uk
Classification:
10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy