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Abstract #6183 Published in IGR 2-2
Soft cannabinoid analogues as potential anti-glaucoma agents
Buchwald A; Browne CE; Wu WM; Ji F; Bodor NPharmazie 2000; 55: 196-201
Cannabinoids have intraocular pressure (IOP) lowering effects, thus, they have a therapeutic potential in the treatment of glaucoma. Unfortunately, in the same time, they show CNS and cardiovascular effects as well. The authors' aim was to develop a safer, cannabinoid type anti-glaucoma agent, a topically applied soft analogue, that has local, but no systemic effect. The lead compound chosen was a nitrogen-containing cannabinoid analogue that was shown to have IOP lowering activity. A full library of possible soft drugs was generated and the structures were ranked based on the closeness of calculated properties to those of the lead compound. The lead compound has been synthesized, and a preliminary pharmacological study was performed. The structure-activity relationship and pharmacological results indicate a good possibility for the development of a safe, soft anti-glaucoma agent. LA: German
Dr. A. Buchwald, Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, FL, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
