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Abstract #6257 Published in IGR 2-2
Mitomycin C dissolved in a reversible thermo-setting gel: effect on aqueous flare in the rabbit eye
Nishimura K; Taniguchi T; Kawase K; Shibahara S; Izumi E; Kumada M; Yamamoto T; Kitazawa Y; Hoshina FNippon Ganka Gakkai Zasshi 2000; 104: 82-85
PURPOSE: To determine the effects of mitomycin C (MMC) dissolved in a gel, which is as effective as a higher dose of aqueous MMC solution, on aqueous flare in rabbits. METHOD: The authors injected subconjunctivally a 0.1 ml solution of MMC containing 30, 10, 3.0, or 0.3 μg of MMC dissolved in a reversible thermo-setting gel in pigmented rabbits. As a control, a 0.1 ml aqueous solution of 30 μg MMC was injected subconjunctivally. Aqueous flare was measured for 28 days after the injection. RESULTS: The aqueous flare in the 30 μg gel group was also level similar to that in the 30 μg aqueous solution group, but the aqueous flare in the 10, 3.0, and 0.3 μg gel groups was significantly lower. The increase in the aqueous flare following the administration of MMC gel was dose-dependent. CONCLUSIONS: The administration of MMC dissolved in a gel can diminish the ocular inflammation by reducing the dose of MMC needed for the antiproliferative effect. LA: Japanese
Dr. K. Nishimura, Department of Ophthalmology, Gifu University School of Medicine, Japan
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
