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(2)

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Abstract #6342 Published in IGR 3-2

The retinal nerve fiber layer defect and its related clinical features in early primary open-angle glaucoma

Li M; Li M.; Fu P
Chinese Journal of Ophthalmology 2001; 37: 193

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OBJECTIVE: To investigate the distribution of diffuse and local retinal nerve fiber layer defects (RNFLD) and their clinical features in early primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG). METHODS: The types of RNFLD in 81 cases with POAG and 70 cases with NTG were observed, the distribution of diffuse and local RNFLD was analyzed, and the maximum untreated intraocular pressure (IOP) and history of optic disc hemorrhage between the two types of RNFLD in the two glaucomatous groups were compared. RESULTS: RNFLD appeared in 78 of 81 cases with POAG, 50 of which were diffuse and 28 local; 27 cases of diffuse and 43 local RNFLD were found in 70 cases with NTG. IOP was 28.78 ± 5.41 mmHg in the diffuse and 26.2 ± 5.2 mmHg in the local type with POAG (t = 2.04, p < 0.05), and 19.2 ± 1.9 mmHg and 17.8 ± 2.0 mmHg, respectively, with NTG (t = 2.94, p < 0.05). The incidence of disc hemorrhage was 10/78 and 18/70 with POAG and NTG, respectively (² = 4, p < 0.05). This was 3/50 in the diffuse and 7/28 in the local type with POAG (² = 4.22, p < 0.05), and 3/27 and 15/43, with NTG (² = 4.91, p < 0.05), respectively. There were no statistic differences in the diffuse type between POAG and NTG groups (² = 0.15, p > 0.05), or in the local type (² = 1.31, p > 0.05). CONCLUSIONS: Diffuse RNFLD tends to be distributed in POAG, while local RNFLD tends to be distributed in NTG. The maximum IOP in eyes with diffuse RNFLD is higher than that in eyes with local RNFLD, in both the POAG and NTG groups. The occurrence of disc hemorrhage is higher in eyes with local RNFLD than in those with diffuse RNFLD in the two groups, respectively. There are differences in clinical features between the two types of RNFLD in early POAG and NTG.LA: Chinese

Dr Mei Li, Department of Ophthalmology, First Hospital of Peking University, Beijing 100034, China

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Classification:

2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)

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