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Abstract #6419 Published in IGR 3-2
Is open-angle glaucoma associated with early menopause? The Rotterdam Study
Hulsman CA; Westendorp IC; Ramrattan RS; Wolfs RC; Witteman JC; Vingerling JR; Hofman A; De Jong PTAmerican Journal of Epidemiology 2001; 154: 138-144
The authors examined the association between age at menopause and open-angle glaucoma (OAG) among women aged > or = 55 years in the population-based Rotterdam Study (1990-1993). Information on age and type of menopause was obtained by interview. Subjects (n = 3, 078) were stratified into three categories according to age at menopause: < 45 years, 45-49 years, and > or = 50 years, with the last group serving as the reference group. Diagnosis of OAG was based on the presence of a glaucomatous visual field defect and glaucomatous optic neuropathy. OAG was diagnosed in 78 women with a natural menopause and 15 women with an artificial menopause. In the category of natural menopause, women who went through menopause before reaching the age of 45 years had a higher risk of OAG than the reference group (odds ratio = 2.6; 95% confidence interval: 1.5, 4.8), after adjustment for age and use of hormone replacement therapy. Among women who went through menopause between the ages of 45 and 49 years, the odds ratio was 1.1 (95% confidence interval: 0.7, 2.0). These findings suggest that early menopause is associated with a higher risk of OAG.
Dr C.A. Hulsman, The Netherlands Ophthalmic Research Institute, Amsterdam, the Netherlands
Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)