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Abstract #6428 Published in IGR 3-2
A clinical investigation on the relationship between nitric oxide and elevation of intraocular pressure in glaucoma
Han Y; Zhang B; Guo XChinese Journal of Ophthalmology 2001; 37: 281
OBJECTIVE: To investigate the role of nitric oxide (NO) in the process of intraocular pressure (IOP) elevation in glaucoma. METHODS: The levels of NO in the plasma and aqueous humor, obtained from 16 patients with acute angle-closure glaucoma (ten female, six male), 29 cases with cataract (13 female, 16 male), and 30 normal volunteers (13 female, 17 male), were detected by high-performance liquid chromatography and expressed with the total NO2 and NO3. RESULTS: It was found that the mean level of NO in the plasma in the glaucoma group was 1390.78 ± 302.95 ng/l, which was significantly lower than in the normal group (2969.37 ± 862.85 ng/l) (t = 2.853, p < 0.01). But in the cataract group, it was 4234.89 ± 1495.23 ng/l, which was significantly higher than in the normal group (t = 4.471, p < 0.01). There was no significant different in the level of NO in the aqueous humor between the glaucoma group (2052.03 ± 694.74 ng/l) and the normal group (1405.83 ± 602.70 ng/l) (t = 1.862, p > 0.05). But in the cataract group, the mean level of NO (2454.67 ± 655.13 ng/l) in the aqueous humor was remarkably increased compared to that in the normal group (t = 2.752, p < 0.01). The rate of the mean content of NO in normal aqueous humor and plasma (aqueous/plasma) was 47.3%, and in the cataract group, 57.95% (p > 0.05). However, in the glaucoma group, the rate was 144.0%. CONCLUSION: The content of NO in the plasma and aqueous humor is related to the elevation of IOP in cases with acute angle-closure glaucoma.LA: Chinese
Dr Y. Han, Department of Ophthalmology, Affiliated Second Hospital, Hebei Medical University, Shijiazhuang 050000, China
Classification:
9.3.1 Acute primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
